Abstract Objective To seek evidence and associations of the neuroprotective mechanism of therapeutic hypothermia in newborns. Research question was: does therapeutic hypothermia reduce damage to the central nervous system and enhance neuroplasticity in newborns with hypoxic-ischemic encephalopathy? Methods Research with inclusion of articles with available summaries and free online access, related to the therapeutic hypothermia in newborn with encephalopathy, in the databases BDENF, MEDLINE, LILACS and SciELO. Results Ten articles were framed within the interest of research. The good prognosis […]